Archive: Cell & molecular biology
Cell & molecular biology 2008 Research Highlights
Stem cell: Supporting factors
Felix Cheung
Published online: 12 November 2008 | doi:10.1038/nchina.2008.269
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et al. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 3, 475–479 (2008).
Top of pageSynaptic development: Making long-term changes this content is Open !
Felix Cheung
Published online: 12 November 2008 | doi:10.1038/nchina.2008.273
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, , & GABAB receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses. Nature Neurosci. doi:10.1038/nn.2215 (2008).
Top of pageVirology: Movement factor
Jane Qiu
Published online: 12 November 2008 | doi:10.1038/nchina.2008.263
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, , & Identification of a movement protein of rice stripe Tenuivirus. J. Virol. doi:10.1128/JVI.01696-08 (2008).
Top of pageImmunology: Powering immunity
Jane Qiu
Published online: 22 October 2008 | doi:10.1038/nchina.2008.247
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et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29, 1–13 (2008).
Top of pageIntestinal stem cells: In search of self-renewal
Felix Cheung
Published online: 15 October 2008 | doi:10.1038/nchina.2008.239
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, & Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature doi: 10.1038/nature07329 (2008).
Top of pageCancer biology: Consequences of changes
Jane Qiu
Published online: 08 October 2008 | doi:10.1038/nchina.2008.233
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et al. Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer. Cancer Res. 68, 7025–7034 (2008).
Top of pageGlucose homeostasis: Sugar boost this content is Open !
Felix Cheung
Published online: 01 October 2008 | doi:10.1038/nchina.2008.228
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et al. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chem. Biol. doi: 10.1038/nchembio.106 (2008).
Top of pageMicroRNA: Fingerprinting diseases
Jane Qiu
Published online: 01 October 2008 | doi:10.1038/nchina.2008.229
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et al. Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. doi: 10.1038/cr.2008.282 (2008).
Top of pageImmunology: Arrestin effects
Jane Qiu
Published online: 24 September 2008 | doi:10.1038/nchina.2008.225
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et al. Nuclear
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-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-
. Mol. Cell 31, 695–707 (2008).Neuron development: The making of polarity
Jane Qiu
Published online: 24 September 2008 | doi:10.1038/nchina.2008.226
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Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus. J. Neurosci. 28, 8832–8843 (2008).
Top of pageAlzheimer's disease: Catch the copper this content is Open !
Jasmine Farsarakis
Published online: 17 September 2008 | doi:10.1038/nchina.2008.215
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et al. Sequestration of copper from
Top of page-amyloid promotes selective lysis by cyclen-hybrid cleavage agents. J. Biol. Chem. doi: 10.1074/jbc.M804722200 (2008).Cancer biology: Invasive power
Jane Qiu
Published online: 17 September 2008 | doi:10.1038/nchina.2008.216
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et al. p70 S6 Kinase promotes epithelial to mesenchymal transition through Snail induction in ovarian cancer cells. Cancer Res. 68, 6524–6532 (2008).
Top of pageCancer biology: Targeted inhibition
Jane Qiu
Published online: 10 September 2008 | doi:10.1038/nchina.2008.209
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et al. Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res. 68, 6533–6540 (2008).
Top of pageStructural biology: Quality control
Jane Qiu
Published online: 03 September 2008 | doi:10.1038/nchina.2008.205
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et al. Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. Proc. Natl Acad. Sci. USA 105, 11939–11944 (2008).
Top of pageProtein trafficking: The missing link this content is Open !
Felix Cheung
Published online: 27 August 2008 | doi:10.1038/nchina.2008.198
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Signal-mediated dynamic retention of glycosyltransferases in the Golgi. Science 321, 404–407 (2008).
Top of pageAvian influenza: Straight from the dragon's mouth this content is Open !
Felix Cheung
Published online: 13 August 2008 | doi:10.1038/nchina.2008.185
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et al. Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus. Nature doi: 10.1038/nature07120 (2008).
Top of pageCoronary cataract: Blindin' crystallin
Felix Cheung
Published online: 06 August 2008 | doi:10.1038/nchina.2008.179
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et al. A novel mutation in CRYBB2 responsible for inherited coronary cataract. Eye doi: 10.1038/eye.2008.222 (2008).
Top of pageUbiquitylation: Stop the Smurfs
Felix Cheung
Published online: 06 August 2008 | doi:10.1038/nchina.2008.180
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et al. Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nature Cell Biol. doi: 10.1038/ncb1760 (2008).
Top of pageLiver disease: Protein to the rescue
Jasmine Farsarakis
Published online: 06 August 2008 | doi:10.1038/nchina.2008.182
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et al. Peroxisome proliferator-activated receptor-
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induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatol. doi: 10.1002/hep.22334 (2008).Immunology: Another role to play this content is Open !
Jasmine Farsarakis
Published online: 30 July 2008 | doi:10.1038/nchina.2008.175
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et al. An essential function for
Top of page-arrestin 2 in the inhibitory signaling of natural killer cells. Nature Immunol. doi: 10.1038/ni.1635 (2008).Apoptosis: Slow down or die
John Fox
Published online: 23 July 2008 | doi:10.1038/nchina.2008.168
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et al. GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. Cell Res. doi: 10.1038/cr.2008.75 (2008).
Top of pageStructural biology: Two to two this content is Open !
Jane Qiu
Published online: 23 July 2008 | doi:10.1038/nchina.2008.169
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Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature doi: 10.1038/nature07089 (2008).
Top of pageImmunology: Knock your SOCS off
Felix Cheung
Published online: 23 July 2008 | doi:10.1038/nchina.2008.172
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et al. Tumor-induced suppressor of cytokine signaling 3 inhibits toll-like receptor 3 signaling in dendritic cells via binding to tyrosine kinase 2. Cancer Res. 68, 5397–5404 (2008).
Top of pageNeurogenesis: Control factors this content is Open !
Felix Cheung
Published online: 16 July 2008 | doi:10.1038/nchina.2008.162
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et al. Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons. Dev. Biol. doi: 10.1016/j.ydbio.2008.06.031 (2008).
Top of pageCholesterol uptake: Stop the cycle
Felix Cheung
Published online: 02 July 2008 | doi:10.1038/nchina.2008.150
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et al. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metab. 7, 508–519 (2008).
Top of pageImmunology: Order please
Jasmine Farsarakis
Published online: 25 June 2008 | doi:10.1038/nchina.2008.144
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et al. Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition. Nature Immunol. doi: 10.1038/ni.1614 (2008).
Top of pageCell metabolism: Fat-gene crackdown this content is Open !
Jasmine Farsarakis
Published online: 18 June 2008 | doi:10.1038/nchina.2008.140
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et al. Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J. doi: 10.1038/emboj.2008.92 (2008).
Top of pageCalcium signalling: Partners in crime
Jane Qiu
Published online: 18 June 2008 | doi:10.1038/nchina.2008.141
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et al. PP2B and PP1
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cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev. 22, 1356–1368 (2008).Cancer therapy: Targeted attacks
Jane Qiu
Published online: 18 June 2008 | doi:10.1038/nchina.2008.142
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et al. Cancer immunotherapy using in vitro genetically modified targeted dendritic cells. Cancer Res. 68, 3854–3862 (2008).
Top of pageImmunology: Too eager to defend
Jane Qiu
Published online: 11 June 2008 | doi:10.1038/nchina.2008.131
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et al. Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc. Natl Acad. Sci. USA 105, 7528–7533 (2008).
Top of pageCancer therapy: Effects of radiation
Jasmine Farsarakis
Published online: 04 June 2008 | doi:10.1038/nchina.2008.129
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et al. Mitochondria-dependent signalling pathway are involved in the early process of radiation-induced bystander effects. Br. J. Cancer doi: 10.1038/sj.bjc.6604358 (2008).
Top of pageNeuron survival: A matter of life and death this content is Open !
Jane Qiu
Published online: 04 June 2008 | doi:10.1038/nchina.2008.130
Original article citation:
Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. J. Neurosci. 28, 4872–4877 (2008).
Top of pageInfectious disease: Deadly factors
Jane Qiu
Published online: 28 May 2008 | doi:10.1038/nchina.2008.121
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et al. SalK/SalR, a two-component signal transduction system, is essential for full virulence of highly invasive Streptococcus suis serotype 2. PLoS One doi: 10.1371/journal.pone.0002080 (2008).
Top of pageDisease genes: Finding the culprits this content is Open !
Tim Reid
Published online: 28 May 2008 | doi:10.1038/nchina.2008.124
Original article citation:
Network-based global inference of human disease genes. Mol. Sys. Biol. 4, 189 (2008).
Top of pageAIDS treatment: The winning count
Felix Cheung
Published online: 21 May 2008 | doi:10.1038/nchina.2008.114
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et al. Association between V
Top of page2V2 T cells and disease progression after infection with closely related strains of HIV in China. Clin. Inf. Dis. 46, 1466–1472 (2008).Cellular shells: A chance for a longer life this content is Open !
Timon Chengyi Liu
Published online: 14 May 2008 | doi:10.1038/nchina.2008.111
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et al. Yeast cells with an artificial mineral shell: Protection and modification of living cells by biomimetic mineralization. Angew. Chem. Int. Ed. 47, 3560–3564 (2008).
Top of pageImmune response: Keeping a balance
Wei Zeng
Published online: 14 May 2008 | doi:10.1038/nchina.2008.112
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et al. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nature Immunol. 9, 542–550 (2008).
Top of pageStem cell: A cocktail recipe
Wei Zeng
Published online: 30 April 2008 | doi:10.1038/nchina.2008.98
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et al. Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors. Cell Res. doi: 10.1038/cr.2008.51 (2008).
Top of pageVascular remodelling: A counter balance this content is Open !
Wei Zeng
Published online: 23 April 2008 | doi:10.1038/nchina.2008.91
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et al. Cross talk among Smad, MAPK, and integrin signalling pathways enhances adventitial fibroblast functions activated by transforming growth factor-
Top of page1 and inhibited by Gax. Arteriosclerosis Thrombosis Vascular Biol. 28, 725–731 (2008). Neural differentiation: Nogo might mean yes this content is Open !
Wei Zeng
Published online: 23 April 2008 | doi:10.1038/nchina.2008.92
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et al. Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR–STAT3 pathway. PLoS ONE 3, e1856 (2008).
Top of pageKinase deactivation: Finding the off switch
Wei Zeng
Published online: 16 April 2008 | doi:10.1038/nchina.2008.85
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et al. Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nature Immunol. doi: 10.1038/ni.1600 (2008).
Top of pageCell migration: Release the brake
Wei Zeng
Published online: 09 April 2008 | doi:10.1038/nchina.2008.77
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et al. Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev. Cell 14, 342–353 (2008).
Top of pageDiabetes: A bittersweet treatment this content is Open !
Felix Cheung
Published online: 09 April 2008 | doi:10.1038/nchina.2008.78
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et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem. Biol. 15, 263–273 (2008).
Top of pageImmune system: Fighting trim this content is Open !
Wei Zeng
Published online: 02 April 2008 | doi:10.1038/nchina.2008.72
Original article citation:
et al. TRIM30
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B activation by targeting TAB2 and TAB3 for degradation. Nature Immunol. doi: 10.1038/ni1577 (2008).RNA interference: End letters hold the key
Wei Zeng
Published online: 02 April 2008 | doi:10.1038/nchina.2008.73
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et al. Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell 133, 1–12 (2008).
Top of pageAirway inflammation: Adenosine action
John Fox
Published online: 02 April 2008 | doi:10.1038/nchina.2008.74
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Adenosine promotes IL-6 release in airway epithelia. J. Immunol. 180, 4173–4181 (2008).
Top of pageCell signalling: String quartet
Felix Cheung
Published online: 02 April 2008 | doi:10.1038/nchina.2008.75
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et al. Nuclear Dvl, c-Jun,
Top of page-catenin, and TCF form a complex leading to stabilization of -catenin–TCF interaction. J. Cell Biol. 180, 1087–1100 (2008).Plant development: Day and night this content is Open !
Jasmine Farsarakis
Published online: 26 March 2008 | doi:10.1038/nchina.2008.66
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et al. Coordinated regulation of Arabidopsis thaliana development by light and gibberelins. Nature 451, 475–480 (2008).
Top of pageCell aging: The pathway to eternal youth
Jasmine Farsarakis
Published online: 26 March 2008 | doi:10.1038/nchina.2008.67
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et al. SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS ONE 3, e1710 (2008).
Top of pageLeaf polarity: Upside down
Wei Zeng
Published online: 26 March 2008 | doi:10.1038/nchina.2008.68
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Ribosomal proteins promote leaf adaxial identity. Development 135, 1325–1334 (2008).
Top of pageHormone synthesis: Love potion of a pathogen this content is Open !
Felix Cheung
Published online: 12 March 2008 | doi:10.1038/nchina.2008.54
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et al. Synthesis and absolute configuration of hormone
Top of page1. Nature Chem. Biol. doi: 10.1038/nchembio.74 (2008).Immune response: Supervision needed
Wei Zeng
Published online: 05 March 2008 | doi:10.1038/nchina.2008.46
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et al. Adaptive immune cells temper initial innate responses. Nature Med. 13, 1248–1252 (2007).
Top of pageCell death: Corpse disposal
Wei Zeng
Published online: 27 February 2008 | doi:10.1038/nchina.2008.45
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et al. C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. Development 135, 1069–1080 (2008).
Top of pageChymotrypsin B: Not just a digestive protease this content is Open !
Jasmine Farsarakis
Published online: 20 February 2008 | doi:10.1038/nchina.2008.32
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et al. Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway. J. Biol. Chem. doi: 10.1074/jbc.M709789200 (2008).
Top of pageSARS virus: Rafting into host cells
John Fox
Published online: 20 February 2008 | doi:10.1038/nchina.2008.33
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et al. SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway. Cell Res. doi: 10.1038/cr.2008.15 (2008).
Top of pageAnticancer agents: A clue to how they work
Jasmine Farsarakis
Published online: 20 February 2008 | doi:10.1038/nchina.2008.37
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et al. An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation–acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-Aza-2'-deoxycytidine treatment. J. Biol. Chem. 283, 2564–2574 (2008).
Top of pageSARS vaccine: A bit spiky this content is Open !
Wei Zeng
Published online: 30 January 2008 | doi:10.1038/nchina.2008.20
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et al. Intra nasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection. J. Immunol. 180, 948–956 (2008).
Top of pagePlant immunity: Born to cheat this content is Open !
Wei Zeng
Published online: 23 January 2008 | doi:10.1038/nchina.2008.16
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et al. Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr. Biol. 18, 74–80 (2008).
Top of pageVirology: The death of viral reservoirs
Jasmine Farsarakis
Published online: 23 January 2008 | doi:10.1038/nchina.2008.17
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Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages. J. Immunol. 180, 898–906 (2008).
Top of pageDNA methylation: Working together
Jasmine Farsarakis
Published online: 10 January 2008 | doi:10.1038/nchina.2007.284
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et al. Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol. Cell Biol. 27, 8748–8759 (2007).
Top of pageBreast cancer: Destroying bad seeds this content is Open !
Wei Zeng
Published online: 10 January 2008 | doi:10.1038/nchina.2007.289
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et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131, 1109–1123 (2007).
Top of pageBacterial pathogens: How they work this content is Open !
Felix Cheung
Published online: 10 January 2008 | doi:10.1038/nchina.2008.5
Original article citation:
et al. Structural basis for the catalytic mechanism of phosphothreonine lyase. Nature Struct. Mol. Biol. doi: 10.1038/nsmb1329 (2007).
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