Archive: Cell & molecular biology
Cell & molecular biology 2010 Research Highlights
Structural biology: The fucose transporter opens out this content is Open !
Timon Chengyi Liu
Published online: 03 November 2010 | doi:10.1038/nchina.2010.118
Original article citation:
et al. Structure of a fucose transporter in an outward-open conformation. Nature 467, 734–738(2010).
Top of pageDrug discovery: Drug search
Timon Chengyi Liu
Published online: 06 October 2010 | doi:10.1038/nchina.2010.106
Original article citation:
& Network-based relating pharmacological and genomic spaces for drug target identification. PLoS ONE 5, e11764 (2010).
Top of pageChemical biology: A new twist in Alzheimer's disease this content is Open !
Anne Pichon
Published online: 06 October 2010 | doi:10.1038/nchina.2010.107
Original article citation:
, , & Alzheimer's disease amyloid beta converting left-handed Z-DNA back to right-handed B-form. Chem. Commun. doi:10.1039/c0cc02049d (2010).
Top of pageImmunology: Complex formation this content is Open !
Felix Cheung
Published online: 06 October 2010 | doi:10.1038/nchina.2010.108
Original article citation:
et al. Structural insights into the assembly and activation of IL-1β with its receptors. Nature Immunol. doi:10.1038/ni.1925 (2010).
Top of pageCell metabolism: Chilli peppers have their benefits this content is Open !
Timon Chengyi Liu
Published online: 01 September 2010 | doi:10.1038/nchina.2010.96
Original article citation:
et al. Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metabolism 12, 130–141 (2010).
Top of pageMicrobiology: Deadly inhibitors
Timon Chengyi Liu
Published online: 01 September 2010 | doi:10.1038/nchina.2010.97
Original article citation:
et al. Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science doi:10.1126/science.1193844 (2010).
Top of pageStructural biology: New insights into potassium channels
Felix Cheung
Published online: 01 September 2010 | doi:10.1038/nchina.2010.98
Original article citation:
, & Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore. Nature Struct. Mol. Biol. doi:10.1038/nsmb.1865 (2010).
Top of pageImmunology: TLR signalling needs some fine-tuning
Felix Cheung
Published online: 04 August 2010 | doi:10.1038/nchina.2010.86
Original article citation:
et al. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nature Immunol. doi:10.1038/ni.1908 (2010).
Top of pageMolecular biology: Eliminate to survive this content is Open !
Felix Cheung
Published online: 04 August 2010 | doi:10.1038/nchina.2010.87
Original article citation:
et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nature Cell Biol. doi:10.1038/ncb2069 (2010).
Top of pageMolecular biology: Good riddance
Felix Cheung
Published online: 04 August 2010 | doi:10.1038/nchina.2010.88
Original article citation:
et al. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nature Cell Biol. doi:10.1038/ncb2082 (2010).
Top of pageMolecular biology: The four steps to autophagy this content is Open !
Felix Cheung
Published online: 04 August 2010 | doi:10.1038/nchina.2010.89
Original article citation:
et al. C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell doi:10.1016/j.cell.2010.04.034 (2010).
Top of pageStructural biology: The funnel of death
Felix Cheung
Published online: 07 July 2010 | doi:10.1038/nchina.2010.77
Original article citation:
et al. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell doi:10.1016/j.cell.2010.03.017 (2010).
Top of pageMedicinal chemistry: How arsenic stops leukaemia
Felix Cheung
Published online: 05 May 2010 | doi:10.1038/nchina.2010.62
Original article citation:
et al. Arsenic trioxide controls the fate of the PML-RARα oncoprotein by directly binding PML. Science 328, 240–243 (2010).
Top of pageCell biology: A channel to stretch this content is Open !
Felix Cheung
Published online: 28 April 2010 | doi:10.1038/nchina.2010.57
Original article citation:
et al. Mechanosensitive gating of CFTR. Nature Cell Biol. doi:10.1038/ncb2053 (2010).
Top of pageMolecular biology: Split or no split
Felix Cheung
Published online: 28 April 2010 | doi:10.1038/nchina.2010.58
Original article citation:
et al. Partitioning of histone H3-H4 tetramers during DNA replication–dependent chromatin assembly. Science 328, 94–98 (2010).
Top of pageStructural biology: Fat loop this content is Open !
Felix Cheung
Published online: 14 April 2010 | doi:10.1038/nchina.2010.49
Original article citation:
et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature doi:10.1038/nature08921 (2010).
Top of pageStructural biology: The carnitine antiporter this content is Open !
Felix Cheung
Published online: 07 April 2010 | doi:10.1038/nchina.2010.45
Original article citation:
, , & Crystal structure of the carnitine transporter and insights into the antiport mechanism. Nature Struct. Mol. Biol. doi:10.1038/nsmb.1788 (2010).
Top of pageOncology: One chromosome's gain is another person's loss this content is Open !
Felix Cheung
Published online: 31 March 2010 | doi:10.1038/nchina.2010.41
Original article citation:
et al. Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nature Cell Biol. doi:10.1038/ncb2039 (2010).
Top of pageMetabolism: The role of acetylation in cells this content is Open !
Felix Cheung
Published online: 17 March 2010 | doi:10.1038/nchina.2010.33
Original article citation:
et al. Regulation of cellular metabolism by protein lysine acetylation. Science 327, 1000–1004 (2010).
Top of pageMetabolism: The role of acetylation in microbes this content is Open !
Felix Cheung
Published online: 17 March 2010 | doi:10.1038/nchina.2010.34
Original article citation:
et al. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 327, 1004–1007 (2010).
Top of pageBehavioural neuroscience: You must remember this this content is Open !
Felix Cheung
Published online: 10 March 2010 | doi:10.1038/nchina.2010.32
Original article citation:
et al. Forgetting is regulated through Rac activity in Drosophila. Cell 140, 579–589 (2010).
Top of pageCell death: Retro recycling this content is Open !
Felix Cheung
Published online: 24 February 2010 | doi:10.1038/nchina.2010.21
Original article citation:
et al. Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Science doi:10.1126/science.1184840 (2010).
Top of pageMolecular neuroscience: Probing the prion hypothesis
Felix Cheung
Published online: 24 February 2010 | doi:10.1038/nchina.2010.24
Original article citation:
, , & Generating a prion with bacterially expressed recombinant prion protein. Science doi:10.1126/science.1183748 (2010).
Top of pageNeuropharmacology: Magnesium is the new brain food this content is Open !
Felix Cheung
Published online: 10 February 2010 | doi:10.1038/nchina.2010.20
Original article citation:
et al. Enhancement of learning and memory by elevating brain magnesium. Neuron 65, 165–177 (2010).
Top of pageMolecular biology: The protein that leads the way
Felix Cheung
Published online: 03 February 2010 | doi:10.1038/nchina.2010.13
Original article citation:
et al. The tight junction protein, occludin, regulates the directional migration of epithelial cells. Dev. Cell doi:10.1016/j.devcel.2009.12.008 (2010).
Top of pageStructural biology: Make up a foursome this content is Open !
Felix Cheung
Published online: 03 February 2010 | doi:10.1038/nchina.2010.14
Original article citation:
et al. Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation. Nature Struct. Mol. Biol. doi:10.1038/nsmb.1760 (2010).
Top of pageStructural biology: Finding the way in this content is Open !
Felix Cheung
Published online: 27 January 2010 | doi:10.1038/nchina.2010.9
Original article citation:
et al. Mechanism of substrate recognition and transport by an amino acid antiporter. Nature doi:10.1038/nature08741 (2010).
Top of pageCell biology: New strategy for tackling Alzheimer's disease
Felix Cheung
Published online: 20 January 2010 | doi:10.1038/nchina.2010.5
Original article citation:
, , , & A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis. Cell Res. doi:10.1038/cr.2010.3 (2010).
Top of pageImmunology: Maintenance is the key this content is Open !
Felix Cheung
Published online: 20 January 2010 | doi:10.1038/nchina.2010.6
Original article citation:
et al. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nature Med. doi:10.1038/nm.2077 (2010).
Top of page
