Archive: Cell & molecular biology
Cell & molecular biology 2012 Research Highlights
Cell migration: Dead in its tracks
Edward Duca
Published online: 02 May 2012 | doi:10.1038/nchina.2012.29
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et al. Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nature Immunol. 13, 457–464 (2012).
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Chemical biology: Nature's way of combating leukaemia this content is Open !
Felix Cheung
Published online: 02 May 2012 | doi:10.1038/nchina.2012.30
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et al. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nature Chem. Biol. doi:10.1038/nchembio.935 (2012).
Top of pageMolecular biology: Expecting mothers beware! this content is Open !
Felix Cheung
Published online: 02 May 2012 | doi:10.1038/nchina.2012.31
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et al. Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature doi:10.1038/nature10897 (2012).
Top of pageCancer biology: The little RNA that makes brain cancer
Edward Duca
Published online: 07 March 2012 | doi:10.1038/nchina.2012.14
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et al. MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop. J. Clin. Invest. 122, 33–47 (2012).
Top of pageCell biology: Recycling mitochondria
Edward Duca
Published online: 07 March 2012 | doi:10.1038/nchina.2012.15
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et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nature Cell Biol. 14, 177–185 (2012).
Top of pageMolecular biology: Extra creamy this content is Open !
Edward Duca
Published online: 07 March 2012 | doi:10.1038/nchina.2012.16
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et al. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nature Med. 18, 235–243 (2012).
Top of pageStructural biology: A tale with a twist
Felix Cheung
Published online: 07 March 2012 | doi:10.1038/nchina.2012.17
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et al. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science 335, 720–723 (2012).
Top of pageMolecular neuroscience: New hope for epilepsy
Edward Duca
Published online: 01 February 2012 | doi:10.1038/nchina.2012.11
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et al. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nature Neurosci. doi:10.1038/nn.3006 (2011).
Top of pageCell biology: The mediator of death this content is Open !
Felix Cheung
Published online: 01 February 2012 | doi:10.1038/nchina.2012.8
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et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213–227 (2012).
Top of pageMolecular biology: Cutting the ties that bind this content is Open !
Edward Duca
Published online: 01 February 2012 | doi:10.1038/nchina.2012.9
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et al. Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Nature doi:10.1038/nature10690 (2011).
Top of pageCancer biology: Ridding the seeds of evil this content is Open !
Felix Cheung
Published online: 04 January 2012 | doi:10.1038/nchina.2012.1
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et al. Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res. 71, 7238–7249 (2011).
Top of pageStem cells: Pushing for pluripotency
Felix Cheung
Published online: 04 January 2012 | doi:10.1038/nchina.2012.2
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et al. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 4, 611–614 (2011).
Top of pageStructural biology: How to mend a broken DNA
Amanda Yu
Published online: 04 January 2012 | doi:10.1038/nchina.2012.3
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et al. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5′-adenylated DNA. Nature Struct. & Mol. Biol. 18, 1297–1299 (2011).
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