Archive: Genetics
Genetics 2009 Research Highlights
Medical genetics: The mutation responsible for osteoporosis this content is Open !
Felix Cheung
Published online: 23 December 2009 | doi:10.1038/nchina.2009.243
Original article citation:
et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J. Clin. Invest. 119, 3666–3677 (2009).
Top of pageHuman evolution: Finding roots on the Tibetan Plateau this content is Open !
Felix Cheung
Published online: 16 December 2009 | doi:10.1038/nchina.2009.236
Original article citation:
et al. Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau. Proc. Natl Acad. Sci. USA 106, 21230–21235 (2009).
Top of pageGenomics: Panda genome decoded this content is Open !
Felix Cheung
Published online: 16 December 2009 | doi:10.1038/nchina.2009.237
Original article citation:
et al. The sequence and de novo assembly of the giant panda genome. Nature doi:10.1038/nature08696 (2009).
Top of pageOncology: Prepare for an invasion this content is Open !
Felix Cheung
Published online: 09 December 2009 | doi:10.1038/nchina.2009.233
Original article citation:
et al. The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J. Clin. Invest. doi:10.1172/JCI39374 (2009).
Top of pageGenomics: The greatest thing since sliced cucumber this content is Open !
Felix Cheung
Published online: 11 November 2009 | doi:10.1038/nchina.2009.219
Original article citation:
et al. The genome of the cucumber, Cucumis sativus L. Nature Genet. doi:10.1038/ng.475 (2009).
Top of pageImmunology: Decoding multiple sclerosis this content is Open !
Felix Cheung
Published online: 28 October 2009 | doi:10.1038/nchina.2009.208
Original article citation:
et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nature Immunol. doi:10.1038/ni.1798 (2009).
Top of pageDermatology: Newly discovered lupus loci this content is Open !
Felix Cheung
Published online: 28 October 2009 | doi:10.1038/nchina.2009.210
Original article citation:
et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nature Genet. doi:10.1038/ng.472 (2009).
Top of pageNeurology: Memory unlocked
Felix Cheung
Published online: 14 October 2009 | doi:10.1038/nchina.2009.202
Original article citation:
et al. Preferential enhancement of working memory in mice lacking adenosine A2A receptors. Brain Res. doi:10.1016/j.brainres.2009.09.082 (2009).
Top of pageGenomics: Silkworm secrets this content is Open !
Felix Cheung
Published online: 16 September 2009 | doi:10.1038/nchina.2009.183
Original article citation:
et al. Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science doi:10.1126/science.1176620 (2009).
Top of pageCardiology: Heart therapy this content is Open !
Felix Cheung
Published online: 02 September 2009 | doi:10.1038/nchina.2009.174
Original article citation:
et al. Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction. Circulation doi:10.1161/CIRCULATIONAHA.109.870725 (2009).
Top of pageGenomics: Mere differences
Felix Cheung
Published online: 02 September 2009 | doi:10.1038/nchina.2009.175
Original article citation:
et al. Centromere repositioning in cucurbit species: Implication of the genomic impact from centromere activation and inactivation. Proc. Natl Acad. Sci. doi:10.1073/pnas.0904833106 (2009).
Top of pageMedical genetics: Key to longevity this content is Open !
Felix Cheung
Published online: 19 August 2009 | doi:10.1038/nchina.2009.166
Original article citation:
et al. Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population. PLoS ONE 4, e6423 (2009).
Top of pageGenomics: Parasitic flatworms deciphered
Felix Cheung
Published online: 29 July 2009 | doi:10.1038/nchina.2009.154
Original article citation:
et al. The Schistosoma japonicum genome reveals features of host–parasite interplay. Nature doi:10.1038/nature08140 (2009).
Top of pageInfectious diseases: Swine flu origin unwrapped this content is Open !
Felix Cheung
Published online: 24 June 2009 | doi:10.1038/nchina.2009.133
Original article citation:
et al. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature doi:10.1038/nature08182 (2009).
Top of pageSequencing technology: Snappy snippets this content is Open !
Felix Cheung
Published online: 17 June 2009 | doi:10.1038/nchina.2009.129
Original article citation:
et al. SNP detection for massively parallel whole-genome resequencing. Genome Res. doi:10.1101/gr.088013.108 (2009).
Top of pageMetabolism: Goose liver tells a big fat story
Felix Cheung
Published online: 27 May 2009 | doi:10.1038/nchina.2009.115
Original article citation:
et al. The role of insulin and glucose in goose primary hepatocyte triglyceride accumulation. J. Exp. Biol. 212, 1553–1558 (2009).
Top of pageOncology: Stress factors this content is Open !
Felix Cheung
Published online: 20 May 2009 | doi:10.1038/nchina.2009.113
Original article citation:
et al. Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. Am. J. Hum. Genet. 84, 534–541 (2009).
Top of pageExtremophile biology: Shrimp shield
Felix Cheung
Published online: 13 May 2009 | doi:10.1038/nchina.2009.95
Original article citation:
, , , & Formation of diapause cyst shell in brine shrimp, Artemia parthenogenetica and its resistance role toward environmental stresses. J. Biol. Chem. doi:10.1074/jbc.M109.004051 (2009).
Top of pageRice genetics: On the roll
Felix Cheung
Published online: 29 April 2009 | doi:10.1038/nchina.2009.87
Original article citation:
, , , and SHALLOT-LIKE1 is a KANADI transcription factor that modulates rice leaf rolling by regulating leaf abaxial cell development. Plant Cell doi:10.1105/tpc.108.061457 (2009).
Top of pagePlant physiology: Environmental regulations
Tim Reid
Published online: 15 April 2009 | doi:10.1038/nchina.2009.75
Original article citation:
et al. The Arabidopsis RING finger E3 ligase RHA2a is a novel positive regulator of ABA signaling during seed germination and early seedling development. Plant Physiol. doi:10.1104/pp.109.135269 (2009).
Top of pageRice genetics: Know grain, know gain this content is Open !
Felix Cheung
Published online: 01 April 2009 | doi:10.1038/nchina.2009.64
Original article citation:
et al. Natural variation at the DEP1 locus enhances grain yield in rice. Nature Genet. doi:10.1038/ng.352 (2009).
Top of pageGenomics: A fishing exercise
Jane Qiu
Published online: 25 March 2009 | doi:10.1038/nchina.2009.55
Original article citation:
et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. doi:10.1101/gr.086595.108 (2009).
Top of pageMicroRNA detection: Spot the difference
Tim Reid
Published online: 18 March 2009 | doi:10.1038/nchina.2009.49
Original article citation:
et al. Highly sensitive determination of microRNA using target-primed and branched rolling-circle amplification. Angew. Chem. Int. Ed. doi:10.1002/anie.200805665 (2009).
Top of pageCongenital disorders: Mutation fingered this content is Open !
Felix Cheung
Published online: 11 March 2009 | doi:10.1038/nchina.2009.47
Original article citation:
et al. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature doi:10.1038/nature07862 (2009).
Top of pageOncology: Cancer connection
Felix Cheung
Published online: 25 February 2009 | doi:10.1038/nchina.2009.31
Original article citation:
et al. Localization of TEIF in the centrosome and its functional association with centrosome amplification in DNA damage, telomere dysfunction and human cancers. Oncogene doi:10.1038/onc.2008.503 (2009).
Top of pageDermatology: Hair for you too! this content is Open !
Felix Cheung
Published online: 11 February 2009 | doi:10.1038/nchina.2009.21
Original article citation:
et al. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nature Genet. doi:10.1038/ng.276 (2009).
Top of pageDermatology: New markers for psoriasis
Felix Cheung
Published online: 11 February 2009 | doi:10.1038/nchina.2009.22
Original article citation:
et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nature Genet. doi:10.1038/ng.310 (2009).
Top of pageSpermiogenesis: Heads or tails
Felix Cheung
Published online: 04 February 2009 | doi:10.1038/nchina.2009.14
Original article citation:
et al. RIM-BP3 is a manchette-associated protein essential for spermiogenesis. Development 136, 373–382 (2009).
Top of pageRice genetics: Transcriptome mapped
Felix Cheung
Published online: 21 January 2009 | doi:10.1038/nchina.2009.10
Original article citation:
et al. A transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies. Nature Genet. doi:10.1038/ng.282 (2009).
Top of pageNeurodegenerative diseases: Root of spasm
Jane Qiu
Published online: 14 January 2009 | doi:10.1038/nchina.2009.2
Original article citation:
et al. A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42). Am. J. Hum. Gen. 83, 752–759 (2008).
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