Archive: Genetics
Genetics 2010 Research Highlights
Medical genetics: More genetic markers for psoriasis this content is Open !
Felix Cheung
Published online: 03 November 2010 | doi:10.1038/nchina.2010.124
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et al. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nature Genet. doi:10.1038/ng.690 (2010).
Top of pageMedical genetics: Stay on the good end of diabetes
Felix Cheung
Published online: 03 November 2010 | doi:10.1038/nchina.2010.125
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et al. Genetic variants of the protein kinase C-β1 gene and development of end-stage renal disease in patients with type 2 diabetes. J. Am. Med. Assoc. 304, 881–889(2010).
Top of pageNeonatology: Saving preemies
Felix Cheung
Published online: 06 October 2010 | doi:10.1038/nchina.2010.111
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et al. Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants. J. Clin. Invest. doi:10.1172/jci40196 (2010).
Top of pagePhylogeography: River deep, mountain high
Felix Cheung
Published online: 06 October 2010 | doi:10.1038/nchina.2010.113
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et al. Spiny frogs (Paini) illuminate the history of the Himalayan region and Southeast Asia. Proc. Natl Acad. Sci. USA 107, 13765–13770(2010).
Top of pageGenomics: Long live the queen this content is Open !
Felix Cheung
Published online: 06 October 2010 | doi:10.1038/nchina.2010.114
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et al. Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. Science 329, 1068–1071(2010).
Top of pageMedical genetics: New susceptibility loci for oesophageal cancer
Felix Cheung
Published online: 06 October 2010 | doi:10.1038/nchina.2010.115
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Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nature Genet. doi:10.1038/ng.648 (2010).
Top of pageMedical genetics: A susceptibility locus for hepatocellular carcinoma
Felix Cheung
Published online: 01 September 2010 | doi:10.1038/nchina.2010.101
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et al. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nature Genet. doi:10.1038/ng.638 (2010).
Top of pageMolecular biology: The four steps to autophagy this content is Open !
Felix Cheung
Published online: 04 August 2010 | doi:10.1038/nchina.2010.89
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et al. C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell doi:10.1016/j.cell.2010.04.034 (2010).
Top of pageEvolutionary genetics: Living the high life
Felix Cheung
Published online: 04 August 2010 | doi:10.1038/nchina.2010.91
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et al. Sequencing of 50 human exomes reveals adaptation to high altitude. Science doi:10.1126/science.1190371 (2010).
Top of pageFood biotechnology: Good milk, bad milk this content is Open !
Felix Cheung
Published online: 07 July 2010 | doi:10.1038/nchina.2010.74
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et al. Identification and characterisation of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res. doi:10.1038/cr.2010.80 (2010).
Top of pageGenetic engineering: Cotton bugs
Felix Cheung
Published online: 07 July 2010 | doi:10.1038/nchina.2010.75
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et al. Mirid bug outbreaks in multiple crops correlated with wide-scale adoption of Bt cotton in China. Science doi:10.1126/science.1187881 (2010).
Top of pageVirology: Influenza virus has a new weak spot this content is Open !
Felix Cheung
Published online: 07 July 2010 | doi:10.1038/nchina.2010.76
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et al. Identification of influenza A nucleoprotein as an antiviral target. Nature Biotechnol. doi:10.1038/nbt.1638 (2010).
Top of pageMedical genetics: A new susceptibility locus for vitiligo
Felix Cheung
Published online: 07 July 2010 | doi:10.1038/nchina.2010.83
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et al. Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nature Genet. doi:10.1038/ng.603 (2010).
Top of pageMedical genetics: New susceptibility loci for nasopharyngeal cancer
Felix Cheung
Published online: 07 July 2010 | doi:10.1038/nchina.2010.84
Original article citation:
et al. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nature Genet. doi:10.1038/ng.601 (2010).
Top of pageEpigenetics: Few and far between
Felix Cheung
Published online: 02 June 2010 | doi:10.1038/nchina.2010.68
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et al. Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nature Biotechnol. doi:10.1038/nbt.1626 (2010).
Top of pageRice genetics: The perfect rice is on the rise
Felix Cheung
Published online: 02 June 2010 | doi:10.1038/nchina.2010.69
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et al. Regulation of OsSPL14 by OsmiR156 defines ideal plant architecture in rice. Nature Genet. doi:10.1038/ng.591 (2010).
Top of pageMolecular biology: Split or no split
Felix Cheung
Published online: 28 April 2010 | doi:10.1038/nchina.2010.58
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et al. Partitioning of histone H3-H4 tetramers during DNA replication–dependent chromatin assembly. Science 328, 94–98 (2010).
Top of pageTooth development: Dude, where's my CaR?
Felix Cheung
Published online: 07 April 2010 | doi:10.1038/nchina.2010.47
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et al. Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice. Development 137, 985–992 (2010).
Top of pageMedical genetics: Sweet genes
Felix Cheung
Published online: 24 March 2010 | doi:10.1038/nchina.2010.38
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et al. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS One 5, e9153 (2010).
Top of pageGenomics: Deciphering the gut flora this content is Open !
Felix Cheung
Published online: 10 March 2010 | doi:10.1038/nchina.2010.30
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et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59–67 (2010).
Top of pageMedical genetics: Jagged bones
Felix Cheung
Published online: 03 March 2010 | doi:10.1038/nchina.2010.27
Original article citation:
et al. Association of JAG1 with bone mineral density and osteoporotic fractures: A genome-wide association study and follow-up replication studies. Am. J. Hum. Genet. doi:10.1016/j.ajhg.2009.12.014 (2010).
Top of pageMolecular evolution: The rise of night vision this content is Open !
Felix Cheung
Published online: 10 February 2010 | doi:10.1038/nchina.2010.18
Original article citation:
, , & Parallel and convergent evolution of the dim-light vision gene RH1 in bats (order: Chiroptera) PLoS One 5, e8838 (2010).
Top of pageSequencing technology: Faster assembly
Felix Cheung
Published online: 27 January 2010 | doi:10.1038/nchina.2010.11
Original article citation:
et al. De novo assembly of human genomes with massively parallel short read sequencing. Genome Res. doi:10.1101/gr.097261.109 (2010).
Top of pageMedical genetics: Leprosy markers this content is Open !
Felix Cheung
Published online: 13 January 2010 | doi:10.1038/nchina.2010.2
Original article citation:
et al. Genomewide association study of leprosy. N. Engl. J. Med. 361, 2609–2618 (2009).
Top of pageMedical genetics: Silence of the gene
Felix Cheung
Published online: 13 January 2010 | doi:10.1038/nchina.2010.3
Original article citation:
et al. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J. Clin. Invest. doi:10.1172/JCI38012 (2009).
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