Senior Scientist, In Vivo Oncology/Pharmacology

With a commitment on turning good ideas into innovative, effective medicines for many unmet health needs, AstraZeneca is establishing a global research center in Zhangjiang Hi-tech Park, Shanghai, China: the Innovation Center China (ICC). The initial research area for ICC will be cancer research, with focus on translational science by developing knowledge about Chinese patients, discovering biomarkers for personalized medical needs and better understanding drug mechanisms of action for targeted therapies.

As a newly established global research center, ICC provides many excellent scientific research opportunities in a highly stimulating, diverse scientific environment, an active interaction with key opinion leaders in the related scientific fields, and a competitive career development path. ICC offers competitive salaries, compensation and benefits programs.

You are welcomed to send your CV to Joy.Wang@AstraZeneca.com

Address: Building 7, No. 898 Halei Road, Zhangjiang Hi-Tech Park, Shanghai 201203 China
Tel: 8621-61097812
Fax: 8621-61097700

Position Description:

We are seeking a highly motivated senior scientist with broad hands-on experience in animal tumor models to lead oncology pharmacology studies at AstraZeneca Innovation Center china. The successful candidate will independently design studies and participate in team efforts to establish project-specific animal models of human cancers, and support for in vivo evaluation of oncology drug pipelines.

Major Responsibilities:

• Provide scientific leadership in in vivo oncology and pharmacology studies for drug discovery and development projects
• Familiar with in vivo animal techniques, such as bleeding, dosing, implantation, small animal surgery
• Design and execute in vivo animal xenograft tumor models, such as subcutaneous, orthotopic, metastasis
• Develop novel in vivo tumor models with human primary tumor tissue
• Identify, evaluate and develop disease models for HCC and/or Gastric cancer
• Design and execute PK life-phase and PD/biomarker, and angiogenesis assays
• Tissue culture and PD sample analysis with Western blot, ELISA, FACS
• Perform multi-tasks and participate in several projects simultaneously
• Supervise activities of associates daily, and work closely with scientists from other divisions, such as Cell Science and Translational Medicine, etc
• Possess excellent problem-solving skills
• Organize, report and communicate study outcome to the project team

Minimum Requirements:

• Ph.D in oncology, pharmacology science with a minimum of 3 - 5 years hands-on experience working with animal tumor models
• Demonstrated experience with a variety of oncology-related animal models and a detailed understanding of pathways relevant to oncology
• Excellent written and oral communication skills

Preferred Background:

• In vivo Cancer biology, Pharmacology
• Extensive cell biology and signal transduction research experience

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