Principal Scientist / Team Leader, Biomarker

With a commitment on turning good ideas into innovative, effective medicines for many unmet health needs, AstraZeneca is establishing a global research center in Zhangjiang Hi-tech Park, Shanghai, China: the Innovation Center China (ICC). The initial research area for ICC will be cancer research, with focus on translational science by developing knowledge about Chinese patients, discovering biomarkers for personalized medical needs and better understanding drug mechanisms of action for targeted therapies.

As a newly established global research center, ICC provides many excellent scientific research opportunities in a highly stimulating, diverse scientific environment, an active interaction with key opinion leaders in the related scientific fields, and a competitive career development path. ICC offers competitive salaries, compensation and benefits programs.

You are welcomed to send your CV to Joy.Wang@AstraZeneca.com

Address: Building 7, No. 898 Halei Road, Zhangjiang Hi-Tech Park, Shanghai 201203 China
Tel: 8621-61097812
Fax: 8621-61097700

Position Description:

We are seeking a highly motivated senior scientist with broad hands-on experience in both cell and in vivo assay development to lead our biomarker group at AstraZeneca Innovation Center China. The successful candidate will be able to lead a group to independently design and execute experiments for biomarker assays, validate the assays using both pre-clinical and clinical samples, and deliver the validated biomarker assays for early clinical trials.

Major Responsibilities:

• Provide scientific leadership in identifying and effectively planning of biomarker studies for late stage drug discovery projects
• Design and execute assays using molecular readouts to explore the mechanisms for candidate biomarkers
• Design and execute in vivo and ex vivo biomarker assay using techniques such as Elisa, Bioplex, FACS and Immunohistochemistry
• Experience on blood and tissue acquisition and preparation for biomarker assays
• Effectively work with clinical study teams to evaluate, validate and progress pre-clinical biomarkers for clinical trials
• Operationally support application of validated biomarkers for clinical trials
• Familiar with in vivo efficacy models to explore in vivo PK, PD and efficacy marker relationships
• Organize, report and communicate study outcome to the project team
• Maintain clear records of experimental work and deliver data package for IND filing and early clinical trials
• Perform as an effective leader who supervises and coaches research associates

Minimum Requirements:

• Ph.D in biological science with a minimum of 5 years hands-on experience working with cancer therapeutical agents (e.g. small molecules or/and biologics) in animal models, preferably within the pharmaceutical/biotechnology industry
• Excellent communication skills and an ability to lead team and project are essential
• Current knowledge of agents used in clinical oncology desirable
• A strong scientific curiosity and a "can-do" attitude is required to be successful for this position

Preferred Background:

• Biomarker assay development for oncology drug discovery and development
• In vivo Cancer biology, Pharmacology
• Extensive cell biology and signal transduction research experience

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