Scientist/Sr. Scientist - Drug Metabolism and Bioanalysis

With a commitment on turning good ideas into innovative, effective medicines for many unmet health needs, AstraZeneca is establishing a global research center in Zhangjiang Hi-tech Park, Shanghai, China: the Innovation Center China (ICC). The initial research area for ICC will be cancer research, with focus on translational science by developing knowledge about Chinese patients, discovering biomarkers for personalized medical needs and better understanding drug mechanisms of action for targeted therapies.

As a newly established global research center, ICC provides many excellent scientific research opportunities in a highly stimulating, diverse scientific environment, an active interaction with key opinion leaders in the related scientific fields, and a competitive career development path. ICC offers competitive salaries, compensation and benefits programs.

You are welcomed to send your CV to Joy.Wang@AstraZeneca.com

Address: Building 7, No. 898 Halei Road, Zhangjiang Hi-Tech Park, Shanghai 201203 China
Tel: 8621-61097812
Fax: 8621-61097700

Position Description:

We are seeking a highly motivated scientist/senior scientist with broad hands-on experience in in vitro models of metabolism to predict the in vivo liability of compounds and build in vitro–in vivo correlations, and assess the drug–drug interaction potential of compounds through inhibition of drug metabolism enzymes. The successful candidate will independently design DMPK studies and execute experiments to support AZ oncology projects in ICC.

Major Responsibilities:

• To effectively perform in vitro metabolism experiments independently and working as part of a team. To assist colleagues as required
• To derive, summarise and tabulate data using computer packages, for incorporation into reports/databases according to agreed timelines
• To develop/perform methods and identify/resolve problems from ADME and/or PK studies to achieve project objectives
• To deliver high quality scientific results to agreed completion dates for several concurrent studies and schedule own work in agreement with supervisor so that project deadlines are achieved
• To maintain an awareness of current scientific development relevant to in vitro metabolism DMPK science
• To present and describe work at internal/external meetings as appropriate
• To ensure their own work meets AstraZeneca standards
• To ensure their own work is conducted in accordance with local/site safety, health and environment requirements (having received information and training)

Skills and Capabilities:

• Conduct assays (Knowledge of in vitro drug metabolism models and practical enzyme/cell assay experience, LC/MS/MS as plus)
• Derive in vitro assay parameters (Enzyme kinetic knowledge)
• Data interpretation/ integration (ability to relate in vitro parameters to in vivo parameters and an ability to put data into context for compound ADME)
• Independent troubleshooting/new methods/publications (proactive approach to problem solving and strong scientific track record)
• Good verbal and written communication in English and Chinese
• IS/IT skills
• Creativity & Innovation

Minimum Requirements:

Ph.D in DMPK science with a minimum of 3 years hands-on experience, MS with more than 6 year experience. Prefer oncology drug discovery experience in industry

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